Biomedical

Canid progesterone receptors lack activation function 3 domain-dependent activity

Type of publication: 
Matching Publication
Authors: 
A. Gracanin, M.E. van Wolferen, C.A. Sartorius, A.B. Brenkman, W.G. Schoonen, J.A. Mol
Authors from the NMC: 
Published in: 
Endocrinology
Date of publication: 
2012/12
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2012; 153(12):6104-13
DOI: 
10.1210/en.2012-1793

Pref-1 preferentially inhibits heat production in brown adipose tissue

Type of publication: 
Matching Publication
Authors: 
M. Rakhshandehroo, A. Koppen, E. Kalkhoven
Authors from the NMC: 
Published in: 
The Biochemical Journal
Date of publication: 
2012/05
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2012; 443 (3) : e3-5
DOI: 
10.1042/BJ20120382

A patient with congenital generalized lipodystrophy due to a novel mutation in BSCL2: indications for secondary mitochondrial dysfunction

Type of publication: 
Matching Publication
Authors: 
E.H. Jeninga, M. de Vroede, N. Hamers, J.M. Breur, N.M. Verhoeven-Duif, R. Berger, E. Kalkhoven
Published in: 
JIMD Reports
Date of publication: 
2012/08
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2012; 4, 47-54
DOI: 
10.1007/8904_2011_86.

Adipose tissue quantity and composition contribute to adipokine concentrations in the subclavian vein and the inferior mesenteric vein

Type of publication: 
Matching Publication
Authors: 
D.R. Faber, F.L. Moll, A. Vink, C. van der Waal, E. Kalkhoven, H.S. Schipper, G.R. Hajer, H. Monajemi, F.L. Visseren
Authors from the NMC: 
Published in: 
International Journal of Obesity
Date of publication: 
2012/08
Status of the publication: 
Published/accepted
Theme: 

BACKGROUND:

Adipose tissue dysfunction is associated with inflammation, type 2 diabetes mellitus and vascular diseases. Visceral adipose tissue (VAT)-derived adipokines, which are released in the portal circulation may influence liver metabolism.

Theme: 
Pages: 
2012; 36, 1078-1085
DOI: 
10.1038/ijo.2011.214

A novel RNAi lethality rescue screen to identify regulators of adipogenesis

Type of publication: 
Matching Publication
Authors: 
O. van Beekum, Y. Gao, R. Berger, A. Koppen, E. Kalkhoven
Authors from the NMC: 
Published in: 
PLoS ONE
Date of publication: 
2012/06
Status of the publication: 
Published/accepted
Theme: 
Theme: 
DOI: 
10.1371/journal.pone.0037680

Ethics: Genetic testing for MEN1--whose responsibility?

Type of publication: 
Matching Publication
Authors: 
C.J. Lips, J.W. Höppener
Authors from the NMC: 
Published in: 
Nature reviews. Endocrinology
Date of publication: 
2012/10
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2012; 8, 575-576
DOI: 
10.1038/nrendo.2012.164

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms

Type of publication: 
Matching Publication
Authors: 
D.A. Hollman, A. Milona, K.J. van Erpecum, S.W. van Mil
Published in: 
Biochimica et Biophysica Acta
Date of publication: 
2012/11
Status of the publication: 
Published/accepted
Theme: 

The farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor (NR) superfamily. FXR plays an important role in positively regulating genes (transactivation) involved in bile acid homeostasis, fat and glucose metabolism. Recently, it has become clear that an additional important role for FXR consists of downregulating genes involved in inflammation. Because of this broad spectrum of regulated genes, therapeutically targeting FXR with full agonists will likely result in adverse side effects, in line with what is described for other NRs.

Theme: 
Pages: 
2012; 1821(11):1443-1452
DOI: 
10.1016/j.bbalip.2012.07.004

A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid

Type of publication: 
Matching Publication
Authors: 
J.J. Luykx, C.H. Vinkers, S.C. Bakker, W.F. Visser, L. van Boxmeer, E. Strengman, K.R. van Eijk, J.A. Lens, P. Borgdorff, P. Keijzers, T.H. Kappen, E.P. van Dongen, P. Bruins, N.M. Verhoeven, T.J. de Koning, R.S. Kahn, R.A. Ophoff
Authors from the NMC: 
Published in: 
Neuropsychopharmacology
Date of publication: 
2012/08
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2012; 37 (9), 2088-2092
DOI: 
10.1038/npp.2012.57

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression

Type of publication: 
Matching Publication
Authors: 
W.I. Vonk, P. de Bie, C.G. Wichers, P.V. van den Berghe, R. van der Plaats, R. Berger, C. Wijmenga, L.W. Klomp, B. van de Sluis
Authors from the NMC: 
Published in: 
Cellular and Molecular Life Sciences
Date of publication: 
2012/01
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2012; 69 (1), 149-163
DOI: 
10.1007/s00018-011-0743-1

Vitamin B6 vitamer concentrations in cerebrospinal fluid differ between preterm and term newborn infants

Type of publication: 
Matching Publication
Authors: 
M. Albersen, F. Groenendaal, M. van der Ham, T.J. de Koning, M. Bosma, W.F. Visser, G. Visser, M.G. de Sain-van der Velden, N.M. Verhoeven-Duif
Authors from the NMC: 
Published in: 
Pediatrics
Date of publication: 
2012/07
Status of the publication: 
Published/accepted
Theme: 

BACKGROUND AND OBJECTIVE:

Vitamin B(6) plays a pivotal role in brain development and functioning. Differences in vitamin B(6) homeostasis between preterm and term newborn infants have been reported. The authors sought to investigate whether B(6) vitamers in cerebrospinal fluid (CSF) of preterm and term newborn infants are different.

Theme: 
Pages: 
2012; 130 (1), e191-198
DOI: 
10.1542/peds.2011-3751