Biomedical

Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome.

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Pages:

2012; 7 (1): e30332

DOI:

10.1371/journal.pone.0030332

Perspective: All systems go

Type of publication:

Matching Publication

Authors:

J. van der Greef

Authors from the NMC:

http://www.nature.com/nature/journal/v480/n7378_supp/pdf/480S87a.pdf

Published in:

Nature

Date of publication:

2011/12

Link to publication:

Status of the publication:

Published/accepted

Theme:

Source:

Sino Dutch Institute for Preventive and Personalized Medicine

Theme:

Pages:

2011; 480: S87

DOI:

10.1038/480S87a

Lipodomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins

Type of publication:

Matching Publication

Authors:

S.C. Bergheanu, T.H. Reijmers, A.H. Zwinderman, I. Bobeldijk, R. Ramaker, A.H. Liem, J. van der Greef, T. Hankemeier, J.W. Jukema

Authors from the NMC:

Ivana Bobeldijk-Pastorova

Published in:

Current Medical Research & Opinion

Date of publication:

2008/09

Link to publication:

http://informahealthcare.com/doi/abs/10.1185/03007990802321709

Status of the publication:

Published/accepted

Theme:

OBJECTIVE:

Theme:

Pages:

2008; 24 (9): 2477-2487

DOI:

10.1185/03007990802321709

Similarities and differences in lipidomics profiles among healthy monoygotic twin pairs

Type of publication:

Matching Publication

Authors:

H.H.M. Draisma, T.H. Reijmers, I. Bobeldijk-Pastorova, J.J. Meulman, G.F. Estourgie-van Burk, M. Bartels, R. Ramaker, J. van der Greef, D.I. Boomsma, T. Hankemeier

Authors from the NMC:

Ivana Bobeldijk-Pastorova

Published in:

Omics

Date of publication:

2008/03

Link to publication:

http://online.liebertpub.com/doi/pdf/10.1089/omi.2007.0048

Status of the publication:

Published/accepted

Theme:

Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is therefore an important part of the phenotype. Nevertheless, it has not yet been examined to what extent individuals sharing part of their genome and/or environment indeed have similar metabolomes.

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Pages:

2008; 12 (1): 17-31

DOI:

10.1089/omi.2007.0048

RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model

Type of publication:

Matching Publication

Authors:

C.X. Hu, J. van Dommelen, R. van der Heijden, G. Spijksma, T.H. Reijmers, M. Wang, G. Xu, E. Slee, X. Lu, J. van der Greef, T. Hankemeier

Authors from the NMC:

http://pubs.acs.org/doi/abs/10.1021/pr800373m

Published in:

Journal of Proteome Research

Date of publication:

2008/10

Link to publication:

Status of the publication:

Published/accepted

Theme:

A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometric method was developed for the profiling of lipids in human and mouse plasma. With the use of a fused-core C₈ column and a binary gradient, more than 160 lipids belonging to eight different classes were detected in a single LC-MS run.

Theme:

http://onlinelibrary.wiley.com/doi/10.1002/ptr.2753/pdf

Pages:

2008; 7 (11): 4982-4991

DOI:

10.1021/pr800373m

The influence of adaptogens on ultraweak biophoton emission: a pilot experiment

Type of publication:

Matching Publication

Authors:

F.W.G. Schutgens, P. Neogi, E.P.A. van Wijk, R. van Wijk, G. Wikman, F.A.C. Wiegant

Authors from the NMC:

Eduard van Wijk

Published in:

Phytotherapy Research

Date of publication:

2009/08

Link to publication:

Status of the publication:

Published/accepted

Theme:

In the present study, the effect of plant adaptogens (Rhodiola rosea and ADAPT-232) on human photon emission has been determined.

Theme:

http://dx.doi.org/10.1089/pho.2008.2373

Pages:

2009; 23 (8): 1103-1108

DOI:

10.1002/ptr.2753

Biophoton detection and low-intensity light therapy: a potential clinical partnership

Type of publication:

Matching Publication

Authors:

J. Tafur, E.P.A. van Wijk, R. van Wijk, P. Mills

Authors from the NMC:

Eduard van Wijk

Published in:

Photomedicine and Laser Surgery

Date of publication:

2010/02

Link to publication:

Status of the publication:

Published/accepted

Theme:

Theme:

Pages:

2010; 28 (1): 23–30

DOI:

10.1089/pho.2008.2373

Sub-typing of rheumatic diseases based on a systems diagnosis questionnaire

Type of publication:

NMC Publication

Authors:

H.A. van Wietmarschen, T.H. Reijmers, A.J. van der Kooij, J. Schroen, H. Wei, T. Hankemeier, J.J. Meulman, J. van der Greef

Authors from the NMC:

herman van wietmarschen

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024846

Published in:

PLoS ONE

Date of publication:

2011/09

Link to publication:

Status of the publication:

Published/accepted

Theme:

Source:

Sino Dutch Institute for Preventive and Personalized Medicine

BACKGROUND:

The future of personalized medicine depends on advanced diagnostic tools to characterize responders and non-responders to treatment. Systems diagnosis is a new approach which aims to capture a large amount of symptom information from patients to characterize relevant sub-groups.

Theme:

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/c1mb05254c

Pages:

2011; 6 (9): e24846

DOI:

10.1371/journal.pone.0024846

Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats

Type of publication:

Matching Publication

Authors:

C. Hu, H. Wei, H. Kong, J. Bouwman, V. Gonzalez-Covarrubias, R. van der Heijden, T.H. Reijmers, X. Bao, E.R. Verheij, T. Hankemeier, G. Xu, J. van der Greef, M. Wang

Authors from the NMC:

Published in:

Molecular Biosystems

Date of publication:

2011/09

Link to publication:

Status of the publication:

Published/accepted

Theme:

Source:

Sino Dutch Institute for Preventive and Personalized Medicine

Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between their therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-year-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes.

Theme:

Pages:

2011; 7, 3094-3103

DOI:

10.1039/c1mb05254c

Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients

Type of publication:

NMC Publication

Authors:

H.A. van Wietmarschen, K. Yuan, C. Lu, P. Gao, J. Wang, C. Xiao, X. Yan, M. Wang, J. Schroën, A. Lu, G. Xu, J. van der Greef

Authors from the NMC:

herman van wietmarschen

Published in:

Journal of Clinical Rheumatology

Date of publication:

2009/10

Status of the publication:

Published/accepted

Theme:

Source:

Sino Dutch Institute for Preventive and Personalized Medicine

BACKGROUND:

Complex chronic diseases such as rheumatoid arthritis have become a major challenge in medicine and for the pharmaceutical industry. New impulses for drug development are needed.

Theme: