Biomedical
Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy
Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX
Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis
Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds
OBJECTIVE:
To evaluate alterations in skeletal muscle carnitine metabolism during exercise and training by measuring changes in plasma acylcarnitine concentrations in Standardbreds.
ANIMALS:
10 Standardbred geldings with a mean +/- SD age of 20 +/- 2 months and weight of 384 +/- 42 kg.
Systems pharmacology, biomarkers, and biomolecular networks
Correlation network analysis for data integration and biomarker selection
Imaging of ultra-weak photon emission in a rheumatoid arthritis mouse model
Ultra-weak photon emission (UPE) of a living system received scientific attention because of its potential for monitoring increased levels of reactive oxygen species (ROS) in the pathogenesis of rheumatoid arthritis (RA). In this study, a highly sensitive cryogenic charge-coupled device (CCD) camera was used to monitor in a RA mouse model the photon emission both without and with luminol. For that purpose, arthritis was induced in mice utilizing a repeated co-administration of type II collagen with lipopolysaccharide.