Biomedical

Designing antibodies for the inhibition of gastrin activity in tumoral cell lines

Type of publication: 
Matching Publication
Authors: 
R. Barderas, S. Shochat, P. Timmerman, M.J. Hollestelle, J.L. Martínez-Torrecuadrada, J.W. Höppener, D. Altschuh, R. Meloen, J.I. Casal
Authors from the NMC: 
Jo Höppener
Published in: 
International Journal of Cancer
Date of publication: 
2008/05
Link to publication: 
http://dx.doi.org/10.1002/ijc.23395
Status of the publication: 
Published/accepted
Theme: 
Biomedical

Gastrin and its derivatives are becoming important targets for immunotherapy of pancreatic, gastric and colorectal tumors. This study was conducted to design antibodies able to block gastrin binding to the gastrin/cholecystokinin-2 (CCK-2) receptor in order to delay tumor growth.

Theme: 
Biomedical
Pages: 
2008; 122 (10): 2351-2359
DOI: 
10.1002/ijc.23395

Cerebrospinal fluid D-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients

Type of publication: 
Matching Publication
Authors: 
S.A. Fuchs, M.M. de Barse, F.E. Scheepers, W. Cahn, L. Dorland, M.G. de Sain-van der Velden, L.W. Klomp, R. Berger, R.S. Kahn, T.J. de Koning
Authors from the NMC: 
Ruud Berger
M.G.deSain
Published in: 
European Neuropsychopharmacology
Date of publication: 
2008/05
Link to publication: 
http://ac.els-cdn.com/S0924977X07002477/1-s2.0-S0924977X07002477-main.pdf?_tid=1…
Status of the publication: 
Published/accepted
Theme: 
Biomedical
Theme: 
Biomedical
Pages: 
2008; 18 (5): 333-338
DOI: 
10.1016/j.euroneuro.2007.12.002

Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction

Type of publication: 
Matching Publication
Authors: 
M.J. Hollestelle, P. Timmerman, R.H. Meloen, J.W. Höppener
Authors from the NMC: 
Jo Höppener
Published in: 
Endocrine-related Cancer
Date of publication: 
2008/03
Link to publication: 
http://erc.endocrinology-journals.org/cgi/pmidlookup?view=long&pmid=18310296
Status of the publication: 
Published/accepted
Theme: 
Biomedical
Theme: 
Biomedical
Pages: 
2008; 15 (1): 301-309
DOI: 
10.1677/ERC-07-0206

Synergistic effect of oncogenic RET and loss of p18 on medullary thyroid carcinoma development

Type of publication: 
Matching Publication
Authors: 
W. van Veelen, C.J. van Gasteren, D.S. Acton, D.S. Franklin, R. Berger, C.J. Lips, J.W. Höppener
Authors from the NMC: 
Ruud Berger
Jo Höppener
Published in: 
Cancer Research
Date of publication: 
2008/03
Link to publication: 
http://cancerres.aacrjournals.org/content/68/5/1329.full.pdf+html
Status of the publication: 
Published/accepted
Theme: 
Biomedical
Theme: 
Biomedical
Pages: 
2008; 68 (5):1329-1337, doi: 10.1158/0008-5472.CAN-07-5754
DOI: 
2008; 68 (5):1329-1337, doi: 10.1158/0008-5472.CAN-07-5754

A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma

Type of publication: 
Matching Publication
Authors: 
T.S. Gujral, W. van Veelen, D.S. Richardson, S.M. Myers, J.A. Meens, D.S. Acton, M. Duñach, B.E. Elliott, J.W. Höppener, L.M. Mulligan
Authors from the NMC: 
Jo Höppener
Published in: 
Cancer Research
Date of publication: 
2008/03
Link to publication: 
http://cancerres.aacrjournals.org/content/68/5/1338.full.pdf+html
Status of the publication: 
Published/accepted
Theme: 
Biomedical
Theme: 
Biomedical
Pages: 
2008; 68 (5):1338-1346
DOI: 
10.1158/0008-5472.CAN-07-6052

Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia

Type of publication: 
Matching Publication
Authors: 
M.N. Vissers, M.D. Trip, P.H. Pritchard, P. Tam, T. Lukic, M.G. de Sain-van der Velden, M. de Barse, J.J. Kastelein
Authors from the NMC: 
M.G.deSain
Published in: 
European Journal of Clinical Pharmacology
Date of publication: 
2008/07
Link to publication: 
http://download.springer.com/static/pdf/154/art%253A10.1007%252Fs00228-008-0462-…
Status of the publication: 
Published/accepted
Theme: 
Biomedical

OBJECTIVE:

This study investigated the efficacy, safety, tolerability, and pharmacokinetics of a novel cholesterol absorption inhibitor, FM-VP4, comprising disodium ascorbyl sitostanol phosphate (DASP) and disodium ascorbyl campestanol phosphate (DACP).

Theme: 
Biomedical
Pages: 
2008; 64 (7): 651-661
DOI: 
10.1007/s00228-008-0462-1

Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.

Type of publication: 
Matching Publication
Authors: 
C.M. Westermann, L. Dorland, D.M. Votion, M.G. de Sain-van der Velden, I.D. Wijnberg, R.J. Wanders, W.G. Spliet, N. Testerink, R. Berger, J.P. Ruiter, J.H. van der Kolk
Authors from the NMC: 
M.G.deSain
Ruud Berger
Published in: 
Neuromuscular Disorders
Date of publication: 
2008/05
Link to publication: 
http://ac.els-cdn.com/S0960896608000370/1-s2.0-S0960896608000370-main.pdf?_tid=0…
Status of the publication: 
Published/accepted
Theme: 
Biomedical
Theme: 
Biomedical
Pages: 
2008; 18 (5): 355-364
DOI: 
10.1016/j.nmd.2008.02.007

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

Type of publication: 
Matching Publication
Authors: 
M.F. Engel, L. Khemtémourian, C.C. Kleijer, H.J. Meeldijk, J. Jacobs, A.J. Verkleij, B. de Kruijff, J.A. Killian, J.W. Höppener
Authors from the NMC: 
Jo Höppener
Published in: 
Proceedings of the National Academy of Sciences in the U.S.A.
Date of publication: 
2008/04
Link to publication: 
http://www.pnas.org/content/105/16/6033.long
Status of the publication: 
Published/accepted
Theme: 
Biomedical
Theme: 
Biomedical
Pages: 
2008; 105 (16): 6033-6038
DOI: 
10.1073/pnas.0708354105

Familial disease with a risk of sudden death: a longitudinal study of the psychological consequences of predictive testing for long QT syndrome

Type of publication: 
Matching Publication
Authors: 
K.S. Hendriks, M.M.W.B. Hendriks, E. Birnie, F.J. Grosfeld, A.A. Wilde, J. van den Bout, E.M. Smets, J.P. van Tintelen, H.F. ten Kroode, I.M. van Langen
Authors from the NMC: 
Margriet Hendriks
Published in: 
Heart Rhythm
Date of publication: 
2008/05
Link to publication: 
http://ac.els-cdn.com/S1547527108001173/1-s2.0-S1547527108001173-main.pdf?_tid=c…
Status of the publication: 
Published/accepted
Theme: 
Biomedical

BACKGROUND:

Since 1996, in the Netherlands, cardiac and molecular screening has been performed in families with the long QT syndrome, a potentially life-threatening but treatable cardiac arrhythmia syndrome. The psychological consequences of predictive cardiac and molecular screening in these families are relatively unknown.

OBJECTIVE:

A psychological study was initiated to investigate the extent and course of distress caused by this new form of predictive genetic testing.

Theme: 
Biomedical
Pages: 
2008; 5 (5): 719-724
DOI: 
10.1016/j.hrthm.2008.01.032

Homozygous and heterozygous expression of a novel mutation of the acid-labile subunit

Type of publication: 
Matching Publication
Authors: 
H.A. van Duyvenvoorde, M.J. Kempers, T.B. Twickler, J. van Doorn, W.J. Gerver, C. Noordam, M. Losekoot, M. Karperien, J.M. Wit, A.R. Hermus
Published in: 
European Journal of Endocrinology
Date of publication: 
2008/08
Link to publication: 
http://eje-online.org/content/159/2/113.full.pdf+html
Status of the publication: 
Published/accepted
Theme: 
Biomedical

CONTEXT:

Acid-labile subunit (ALS) deficiency due to homozygous inactivation of the ALS gene (IGFALS) is associated with moderate short stature, and in few cases pubertal delay. The clinical expression of heterozygosity is unknown.

Theme: 
Biomedical
Pages: 
2008; 159 (2): 113-120
DOI: 
10.1530/EJE-08-0081