Nutrition & Health

Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome

Type of publication: 
NMC Publication
Authors: 
D.M. Jacobs, J.C. Fuhrmann, F.A. van Dorsten, D. Rein, S. Peters, E.J.J. van Velzen, B. Hollebrands, R. Draijer, J.P.M. van Duynhoven, U. Garczarek
Published in: 
Journal of Agricultural and Food Chemistry
Date of publication: 
2012/03
Status of the publication: 
Published/accepted
Pages: 
2012; 60 (12): 3078-3085
DOI: 
10.1021/jf2044247

SPE-NMR metabolite sub-profiling of urine

Type of publication: 
NMC Publication
Authors: 
D.M. Jacobs, L. Spiesser, M. Garnier, N. de Roo, F.A. van Dorsten, B. Hollebrands, E.J.J. van Velzen, R. Draaijer, J.P.M. van Duynhoven
Published in: 
Analytical and Bioanalytical chemistry
Date of publication: 
2012/11
Status of the publication: 
Published/accepted
Pages: 
2012; 404 (8): 2349-2361
DOI: 
10.1007/s00216-012-6339-2

Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics

Type of publication: 
NMC Publication
Authors: 
E. Szymańska, J. Bouwman, K. Strassburg, J. Vervoort, A.J. Kangas, P. Soininen, M. Ala-Korpela, J.A. Westerhuis, J.P. van Duynhoven, D.J. Mela, I.A. Macdonald, R.J. Vreeken, A.K. Smilde, D.M. Jacobs
Published in: 
OMICS: A journal of integrative biology
Date of publication: 
2012/12
Status of the publication: 
Published/accepted
Pages: 
2012 Dec;16(12):652-67
DOI: 
10.1089/omi.2012.0062

Gut microbial metabolism of polyphenols from black tea and red wine/grape juice is source-specific and colon-region dependent

Type of publication: 
NMC Publication
Authors: 
F.A. van Dorsten, S. Peters, G. Gross, V. Gomez-Roldan, M. Klinkenberg, R.C.H. de Vos, E.E. Vaughan, J.P. van Duynhoven, S. Possemiers, T. van de Wiele, D.M. Jacobs
Published in: 
Journal of Agricultural and Food Chemistry
Date of publication: 
2012/11
Status of the publication: 
Published/accepted
Pages: 
2-12; 60, 11331-11342
DOI: 
10.1021/jf303165w

A lipidomic analysis approach to evaluate the response to cholesterol-lowering food intake

Type of publication: 
NMC Publication
Authors: 
E. Szymańska, F.A. van Dorsten, J. Troost, I. Paliukhovich, E. van Velzen, M.M.W.B. Hendriks, E.A. Trautwein, J.P.M. van Duynhoven, R.J. Vreeken, A.K. Smilde
Published in: 
Metabolomics
Date of publication: 
2012/10
Status of the publication: 
Published/accepted

Plant sterols (PS) are well known to reduce serum levels of total cholesterol and LDL-cholesterol. Lipidomics potentially provides detailed information on a wide range of individual serum lipid metabolites, which may further add to our understanding of the biological effects of PS. In this study, lipidomics analysis was applied to serum samples from a placebo-controlled, parallel human intervention study (n = 97) of 4-week consumption of two PS-enriched, yoghurt drinks differing in fat content (based on 0.1% vs. 1.5% dairy fat).

Pages: 
2012; 8 (5): 894-906
DOI: 
10.1007/s11306-011-0384-2

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery

Type of publication: 
NMC Publication
Authors: 
K. Strassburg, A.M.L. Huijbrechts, K.A. Kortekaas, J.H. Lindeman, T.L. Pedersen, A. Dane, R. Berger, A. Brenkman, T. Hankemeier, J.P. van Duynhoven, E. Kalkhoven, J.W. Newman, R.J. Vreeken
Published in: 
Analytical and Bioanalytical chemistry
Date of publication: 
2012/09
Status of the publication: 
Published/accepted

Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also referred to as lipid mediators, are (non-) enzymatically generated by oxidation of polyunsaturated fatty acids such as arachidonic acid (AA). A plethora of lipid mediators exist which makes the development of generic analytical methods challenging.

Pages: 
2012 September; 404(5): 1413–1426
DOI: 
10.1007/s00216-012-6226-x

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

Type of publication: 
NMC Publication
Authors: 
B. van Ommen, J. Bouwman, L.O. Dragsted, C.A. Drevon, R. Elliott, P. Groot, J. Kaput, J.C. Mathers, M. Müller, F. Pepping, J. Saito, A. Scalbert, M. Radonjic, P. Rocca-Serra, A. Travis, S. Wopereis, C.T. Evelo
Authors from the NMC: 
Published in: 
Genes & Nutrition
Date of publication: 
2010/09
Status of the publication: 
Published/accepted

The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution in ‘omics’ technologies, it has discipline-specific requirements for analytical and bioinformatic procedures.

Pages: 
2010; 5 (3): 189-203
DOI: 
10.1007/s12263-010-0167-9
Publication data (text): 
Feb, 2010

Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes

Type of publication: 
NMC Publication
Authors: 
J. Bouwman, J.T.W.E. Vogels, S. Wopereis, C.M. Rubingh, S. Bijlsma, B. Ommen
Authors from the NMC: 
Published in: 
BMC Medical Genomics
Date of publication: 
2012/01
Status of the publication: 
Published/accepted

 

Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the effects of treatment difficult to interpret.

DOI: 
10.1186/1755-8794-5-1

Towards identification of polyphenol metabolites in biofluids by SPE-LC-MS-SPE-NMR

Type of publication: 
Matching Publication
Authors: 
M. Klinkenberg, N. de Roo, P. Alexandre, I. Mahlous, D.M. Jacobs, H.-G. Janssen, J.P. van Duynhoven
Published in: 
Magnetic Resonance in Food Science
Date of publication: 
2011/01
Status of the publication: 
Published/accepted
Book: 
Magnetic Resonance in Food Science
Publisher: 
RSC Books, London
Pages: 
161-169
DOI: 
10.1039/9781849732994-00161