Ghent University (UGent)

Ghent University 
Laboratory of Integrative Metabolomics (LIMET)

Prof. Lynn Vanhaecke

Research interests/services: 

LIMET most important A1 papers

  1. P. Vangeenderhuysen, J. Van Arnhem, B. Pomian, M. De Graeve, L. De Commer, G. Falony, J. Raes, A. Zhernakova, J. Fu, L.Y. Hemeryck, Lifelines Cohort study and L. Vanhaecke. A dual UHPLC-HRMS-based fecal metabolomics and lipidomics analysis and automated data processing pipeline for comprehensive gut phenotyping. Anal. Chem., 95 (2013) 8461-8468. doi: 10.1021/acs.analchem.2c05371
  2. M. De Spiegeleer, V. Plekhova, J. Geltmeyer, E. Schoolaert, B. Pomian, V. Singh, K. Wijnant, K. De Windt, V. Paukku, A. De Loof, I. Gies, N. Michels, S. De Henauw, M. De Graeve, K. De Clerck and L. Vanhaecke. Point-of-care applicable metabotyping using biofluid-specific electrospun MetaSAMPs directly amenable to ambient LA-REIMS. Sci. Adv., 9 (2023) eade9933. doi: 10.1126/sciadv.ade9933
  3. M. De Graeve, N. Birse, Y. Hong, C. T. Elliott, L. Y. Hemeryck, and L. Vanhaecke. Multivariate versus machine learning-based classification of rapid evaporative ionisation mass spectrometry spectra towards industry-based large-scale fish speciation. Food Chem., 404, (2023) 134632. doi: 10.1016/j.foodchem.2022.134632
  4. V. Plekhova, L. Van Meulebroek, M. De Graeve, A. Perdones-Montero, M. De Spiegeleer, E. De Paepe, E. Vande Walle, Z. Takats, S.J.S. Cameron and L. Vanhaecke. Rapid ex vivo molecular fingerprinting of biofluids using laser-assisted rapid evaporative ionization mass spectrometry. Nat. Protoc., 16, (2021) 4327-4354. doi: 10.1038/s41596-021-00580-8
  5. L. Van Meulebroek, S. Cameron, V. Plekhova, M. De Spiegeleer, K. Wijnant, N. Michels, S. De Henauw, B. Lapauw, Z. Takats and L. Vanhaecke. Rapid LA-REIMS and comprehensive UHPLC-HRMS for metabolic phenotyping of feces. Talanta, 217, (2020) 121043. doi: 10.3390/v12040393
  6. K. Wijnant, L. Van Meulebroek, B. Pomian, K. De Windt, S. De Henauw, N. Michels and L. Vanhaecke. Validated ultra-high-performance liquid chromatography hybrid high-resolution mass spectrometry and laser-assisted rapid evaporative ionization mass spectrometry for salivary metabolomics. Anal. Chem., 92(7) (2020) 5116-5124. doi: 10.1021/acs.analchem.9b05598
  7. M. De Spiegeleer, M. De Graeve, S. Huysman, A. Vanderbeke, L. Van Meulebroek and L. Vanhaecke. Impact of storage conditions on the human stool metabolome and lipidome: preserving the most accurate fingerprint. Anal. Chim. Acta, 1108 (2020) 79-88. doi: 10.1016/j.aca.2020.02.046
  8. S. Huysman, F. Vanryckeghem, E. De Paepe, F. Smedes, S.A. Haughey, C.T. Elliott, K. Demeestere and L. Vanhaecke. Hydrophilic divinylbenzene for equilibrium sorption of emerging organic contaminants in aquatic matrices. Environ. Sci. Technol., 53(18) (2019) 10803-10812. doi: 10.1021/acs.est.9b01814
  9. M.M. Ulaszewska, C.H. Weinert, A. Trimigno, R. Portmann, L. Andres, R. Cristina Badertscher, L. Brennan, C. Brunius, …, L. Van Meulebroek, L. Vanhaecke, R. Vázquez-Fresno, D. Wishart, G. Vergères. Nutrimetabolomics: An integrative action for metabolomic analyses in human nutritional studies. Mol. Nutr. & Food Res., 63 (2018) 1-38. doi: 10.1002/mnfr.201800384
  10. L. Van Meulebroek, E. De Paepe, V. Vercruysse, B. Pomian, S. Bos, B. Lapauw and L. Vanhaecke. Holistic lipidomics of the human gut phenotype using validated ultra-high-performance liquid chromatography coupled to hybrid Orbitrap mass spectrometry. Anal. Chem., 89(22) (2017) 12502-12510. doi: 10.1021/acs.analchem.7b03606
  11. J. Vanden Bussche, M. Marzorati, D. Laukens and L. Vanhaecke. A validated high-resolution mass spectrometry-based approach for metabolomic fingerprinting of the human gut phenotype. Anal. Chem., 87(21) (2015) 10927-10934. doi: 10.1021/acs.analchem.5b02688
  12. K. Wille, H.F. De Brabander, E. De Wulf, P. Van Caeter, C.R. Janssen and L. Vanhaecke. Coupled chromatographic and mass-spectrometric techniques for the analysis of emerging pollutants in the aquatic environment. Trends Anal. Chem., 35 (2012) 87-108. doi: 10.1016/j.trac.2011.12.003

 

 

Contact person: 
Lynn Vanhaecke