Biomedical

Various components of the insulin-like growth factor system in tumor tissue, cerebrospinal fluid and peripheral blood of pediatric medulloblastoma and ependymoma patients

Type of publication: 
Matching Publication
Authors: 
J.M. de Bont, J. van Doorn, R.E. Reddingius, G.H. Graat, M.M. Passier, M.L. den Boer, R. Pieters
Published in: 
International Journal of Cancer
Date of publication: 
2008/08
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 123 (3): 594-600
DOI: 
10.1002/ijc.23558

Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells

Type of publication: 
Matching Publication
Authors: 
I.S. Song, H.H. Chen, I. Aiba, A. Hossain, Z.D. Liang, L.W. Klomp, M.T. Kuo
Published in: 
Molecular Pharmacology
Date of publication: 
2008/09
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 74 (3): 705-713
DOI: 
10.1124/mol.108.046771

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Type of publication: 
Matching Publication
Authors: 
N. Jelluma, A.B. Brenkman, N.J. van den Broek, C.W. Cruijsen, M.H. van Osch, S.M. Lens, R.H. Medema, G.J. Kops
Authors from the NMC: 
Published in: 
Cell
Date of publication: 
2008/01
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 132 (2): 233-246
DOI: 
10.1016/j.cell.2007.11.046

Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitus

Type of publication: 
Matching Publication
Authors: 
L. Khemtémourian, J.A. Killian, J.W. Höppener, M.F. Engel
Authors from the NMC: 
Published in: 
Experimental Diabetes Research
Date of publication: 
2008/02
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 2008: 421287
DOI: 
10.1155/2008/421287

Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus

Type of publication: 
Matching Publication
Authors: 
J.W. Höppener, H.M. Jacobs, N. Wierup, G. Sotthewes, M. Sprong, P. de Bos, R. Berger, F. Sundler, B. Ahrén
Authors from the NMC: 
Published in: 
Experimental Diabetes Research
Date of publication: 
2008/02
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 2008: 697035 (8 pages)
DOI: 
10.1155/2008/697035

Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1

Type of publication: 
Matching Publication
Authors: 
H.H. Chen, I.S. Song, A. Hossain, M.K. Choi, Y. Yamane, Z.D. Liang, J. Lu, L.Y. Wu, Z.H. Siddik, L.W. Klomp, N. Savaraj, M.T. Kuo
Published in: 
Molecular Pharmacology
Date of publication: 
2008/09
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 74 (3): 697-704
DOI: 
10.1124/mol.108.047969

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

Type of publication: 
Matching Publication
Authors: 
N. Jelluma, A.B. Brenkman, I. McLeod, J.R. Yates 3rd, D.W. Cleveland, R.H. Medema, G.J. Kops
Authors from the NMC: 
Published in: 
PLoS ONE
Date of publication: 
2008/06
Status of the publication: 
Published/accepted
Theme: 

BACKGROUND:

Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent merotelic attachments that result in lagging chromosomes during anaphase.

Theme: 
Pages: 
2008; 3 (6): e2415
DOI: 
10.1371/journal.pone.0002415

Yield of additional metabolic studies in neurodevelopmental disorders

Type of publication: 
Matching Publication
Authors: 
H.M. Engbers, R. Berger, P. van Hasselt, T. de Koning, M.G. de Sain-van der Velden, H.Y. Kroes, G. Visser
Authors from the NMC: 
Published in: 
Annals of Neurology
Date of publication: 
2008/08
Status of the publication: 
Published/accepted
Theme: 
Theme: 
Pages: 
2008; 64 (2): 212-217
DOI: 
10.1002/ana.21435

Two mass-spectrometric techniques for quantifying serine enantiomers and glycine in cerebrospinal fluid: potential confounders and age-dependent ranges

Type of publication: 
Matching Publication
Authors: 
S.A. Fuchs, M.G. de Sain-van der Velden, M.M. de Barse, M.W. Roeleveld, M.M.W.B. Hendriks, L. Dorland, L.W. Klomp, R. Berger, T.J. de Koning
Published in: 
Clinical Chemistry
Date of publication: 
2008/09
Status of the publication: 
Published/accepted
Theme: 

BACKGROUND:

The recent discovery and specific functions of D-amino acids in humans are bound to lead to the revelation of D-amino acid abnormalities in human disorders. Therefore, high-throughput analysis techniques are warranted to determine D-amino acids in biological fluids in a routine laboratory setting.

Theme: 
Pages: 
2008; 54 (9): 1443-1450
DOI: 
10.1373/clinchem.2007.100412

Mdm2 induces mono-ubiquitination of FOXO4

Type of publication: 
Matching Publication
Authors: 
A.B. Brenkman, P.L.J. de Keizer, N.J.F. van den Broek, A.G. Jochemsen, B.M.T. Burgering
Authors from the NMC: 
Published in: 
PLoS ONE
Date of publication: 
2008/07
Status of the publication: 
Published/accepted
Theme: 

BACKGROUND:

Theme: 
Pages: 
2008; 3 (7): e2819
DOI: 
10.1371/journal.pone.0002819.